Sulfinpyrazone
产品说明书
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同义名 : | 苯磺保泰松 ;G-28315;NSC 75925;Anturanil;Anturane;(+/-)-Sulfinpyrazone |
| CAS号 : | 57-96-5 | |
| 货号 : | A108887 | |
| 分子式 : | C23H20N2O3S | |
| 纯度 : | 98% | |
| 分子量 : | 404.481 | |
| MDL号 : | MFCD00057279 | |
| 存储条件： |
Pure form Sealed in dry,Room Temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 35 mg/mL(86.53 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | (±)-Sulfinpyrazone is an orally active and potent uricosuric agent for chronic and intermittent gouty arthritis. Sulfinpyrazone has antithrombotic and platelet inhibitory effects. The normal total dose of sulfinpyrazone as an antithrombotic agent is 800 mg daily. The drug has been used continuously for up to 4 years with no serious adverse reactions or laboratory abnormalities. Sulfinpyrazone is not a substitute for conventional anticoagulant agents (e.g. the coumarin derivatives) in the treatment of venous thrombosis, but is an important drug for the treatment of conditions associated with arterial thrombosis and possibly for the prophylaxis of recurrent venous thrombosis[3]. In rats with kaolin-induced paw oedema this compound is able to restore the markedly prolonged euglobulin clot lysis time in an oral dose of 30 mg/kg, whereas salicylate and dipyridamole are somewhat less active in this respect. Beside these effects, sulfinpyrazone protects rabbits from arachidonate-induced sudden death after a single oral dose of 10 - 30 mg/kg[4]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.47mL 0.49mL 0.25mL |
12.36mL 2.47mL 1.24mL |
24.72mL 4.94mL 2.47mL |
| 参考文献 |
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