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Timosaponin BII

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Chemical Structure| 136656-07-0 同义名 : Prototimosaponin A III;TB-II
CAS号 : 136656-07-0
货号 : A108467
分子式 : C45H76O19
纯度 : 97%
分子量 : 921.074
MDL号 : MFCD11111457
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(114 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(108.57 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Timosaponin BII, a natural product isolated and purified from the rhizomes of Anemarrhena asphodeloides Bunge with antioxidant and anti-dementia activities, can inhibit the up-regulation of BACE1 and reduced the over-production of β-CTF and Aβ in rat retina, which was induced by FeCl3, and may be useful for the treatment of type 2 diabetes.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.09mL

0.22mL

0.11mL

5.43mL

1.09mL

0.54mL

10.86mL

2.17mL

1.09mL
参考文献

[1]Huang JF, Shang L, et al. Timosaponin-BII inhibits the up-regulation of BACE1 induced by ferric chloride in rat retina. BMC Complement Altern Med. 2012 Oct 22;12:189.

[2]Zhou WB, Feng B, et al. Hydrolysis of timosaponin BII by the crude enzyme from Aspergillus niger AS 3.0739. J Asian Nat Prod Res. 2010 Nov;12(11):955-61.