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RS 504393

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Chemical Structure| 300816-15-3 同义名 : -
CAS号 : 300816-15-3
货号 : A108264
分子式 : C25H27N3O3
纯度 : 99%+
分子量 : 417.5
MDL号 : MFCD09038564
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 9 mg/mL(21.56 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 RS 504393 effectively blocks MCP-1-induced chemotaxis with an IC50 of 330 nM and significantly reduces β-hexosaminidase release induced by allergens. It entirely inhibits mast cell degranulation triggered by MCP-1 without allergen priming[4].
作用机制 RS-504393 prevent MCP-1 binding by occupying the inter-helical bundle region on the extracellular side of the receptor.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.40mL

0.48mL

0.24mL

11.98mL

2.40mL

1.20mL

23.95mL

4.79mL

2.40mL
参考文献

[1]Baamonde, Ana., et al. Involvement of glutamate NMDA and AMPA receptors, glial cells and IL-1β in the spinal hyperalgesia evoked by the chemokine CCL2 in mice. Neuroscience Letters (2011), 502(3), 178-181.

[2]Yang, Dong., et al. Roles of CC chemokine receptors (CCRs) on lipopolysaccharide-induced acute lung injury. Respiratory Physiology & Neurobiology (2010), 170(3), 253-259.

[3]Kitagawa, Kiyoki., et al. Blockade of CCR2 ameliorates progressive fibrosis in kidney. American Journal of Pathology (2004), 165(1), 237-246.

[4]Tominaga T, et al. Blocking mast cell-mediated type I hypersensitivity in experimental allergic conjunctivitis by monocyte chemoattractant protein-1/CCR2. Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5181-8.