产品说明书

TMPA

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Chemical Structure| 1258275-73-8 同义名 : -
CAS号 : 1258275-73-8
货号 : A107582
分子式 : C21H32O6
纯度 : 98%+
分子量 : 380.475
MDL号 : -
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(275.97 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 TMPA is characterized as a high-affinity antagonist of Nur77, a mechanism that prompts the liberation and translocation of LKB1 into the cytoplasm, thereby activating AMPKα. This action has significant implications for diabetes management, as TMPA effectively reduces blood glucose levels and mitigates insulin resistance in various models of diabetes, including type II db/db, high-fat diet, and streptozotocin-induced diabetic mice. Furthermore, TMPA demonstrates potential therapeutic value in cancer and T-cell apoptosis regulation by diminishing restimulation-induced cell death (RICD) in human T cells[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.63mL

0.53mL

0.26mL

13.14mL

2.63mL

1.31mL

26.28mL

5.26mL

2.63mL
参考文献

[1]Zhan YY, et al. The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK. Nat Chem Biol. 2012 Nov;8(11):897-904.

[2]Recher, et al. Modulation of T-cell apoptosis by small molecule compounds targeting the nuclear orphan receptor Nur 77. (2018).