BAY 11-7082

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Chemical Structure| 19542-67-7 同义名 : -
CAS号 : 19542-67-7
货号 : A107077
分子式 : C10H9NO2S
纯度 : 98%
分子量 : 207.25
MDL号 : MFCD00712162
存储条件：

Pure form Keep in dark place,Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(506.63 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：

IP 2% DMSO+2% Tween80+40% PEG300+water 4 mg/mL clear

PO 0.5% CMC-Na 60 mg/mL suspension

生物活性
靶点

  • E2 conjugating
描述 BAY 11-7082 acts as an inhibitor of IκBα phosphorylation and NF-κB. It selectively and irreversibly suppresses TNF-α-induced phosphorylation of IκB-α, leading to reduced NF-κB activity and expression of adhesion molecules. Furthermore, BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 with IC50 values of 0.19 μM and 0.96 μM, respectively. Additionally, it hampers gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis, as well as IL-1β secretion in both human and mouse cells [1][2][3][4][5].
细胞研究
细胞系 浓度 检测类型 检测时间 活性说明 数据源
A549 10 µM Function Assay 12 h suppresses Dvl-3 induced activation of p65 25156800
A549 10 μM Function Assay 1 h inhibits the increase of phospho-IκBα in PA103-infected cultures  24612488
A549 1 μM Function Assay 48 h enhances the up-regulation of IκB and subsequent decrease in Bax expression induced by combined stimulation 23900080
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.83mL

0.96mL

0.48mL

24.13mL

4.83mL

2.41mL

48.25mL

9.65mL

4.83mL
参考文献

[1]Mori N, et al. Bay 11-7082 inhibits transcription factor NF-kappaB and induces apoptosis of HTLV-I-infected T-cell lines andprimary adult T-cell leukemia cells. Blood. 2002 Sep 1;100(5):1828-1834.

[2]Ritorto MS, et al. Screening of DUB activity and specificity by MALDI-TOF mass spectrometry. Nat Commun. 2014 Aug 27;5:4763.

[3]Strickson S, et al. The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system. Biochem J. 2013 May 1;451(3):427-437.

[4]Pierce JW, et al. Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J Biol Chem. 1997 Aug 22;272(34):21096-103.

[5]Chen L , et al. BAY 11-7082, a nuclear factor-κB inhibitor, induces apoptosis and S phase arrest in gastriccancer cells. J Gastroenterol. 2014 May;49(5):864-74.