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Parthenolide

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Chemical Structure| 20554-84-1 同义名 : (-)-Parthenolide
CAS号 : 20554-84-1
货号 : A105353
分子式 : C15H20O3
纯度 : 97% HPLC
分子量 : 248.317
MDL号 : -
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(422.85 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • HDAC1

  • NF-κB
描述 Parthenolide (PTL) is a sesquiterpene lactone which can induce apoptosis in cancer cells and eradicate cancer stem cells such as leukemia stem cells, prostate tumor-initiating cells and so on. Parthenolide (PTL) has a dose-dependent growth inhibition effect on NSCLC cells Calu-1, H1792, A549, H1299, H157, and H460. Moreover, induction of apoptosis, Parthenolide also induces G0/G1 cell cycle arrest in a concentration-dependent manner in A549 cells and G2/M cell cycle arrest in H1792 cells[3]. Parthenolide increased cell viability and inhibited the apoptosis of H2O2‑induced osteoblasts. Parthenolide decreased the levels of reactive oxygen species, MDA (malondialdehyde), LDH (lactate dehydrogenase) and ALP (alkaline phosphatase). SOD (superoxide dismutase) and GPX (glutathione peroxidase) levels were increased by parthenolide in H2O2‑induced osteoblasts[4]. PTL reduced the cell viability and migration rate of lung fibroblasts and inhibited the expression of EMT-related (epithelial-mesenchymal transition) transcription factors in lung epithelial cells. PTL attenuated BLM-induced pulmonary fibrosis and improved the body weight and pathological changes of BLM-treated mice[5]. In addition, PTL directly or indirectly attenuates neuropathy symptoms and promotes M2 microglia/macrophages polarization[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.03mL

0.81mL

0.40mL

20.14mL

4.03mL

2.01mL

40.27mL

8.05mL

4.03mL
参考文献

[1]Gopal YN, Arora TS, Van Dyke MW. Parthenolide specifically depletes histone deacetylase 1 protein and induces cell death through ataxia telangiectasia mutated. Chem Biol. 2007 Jul;14(7):813-23.

[2]Sheehan M, Wong HR, et al.Parthenolide, an inhibitor of the nuclear factor-kappaB pathway, ameliorates cardiovascular derangement and outcome in endotoxic shock in rodents. Mol Pharmacol. 2002 May;61(5):953-63.

[3]Zhao X, Liu X, Su L. Parthenolide induces apoptosis via TNFRSF10B and PMAIP1 pathways in human lung cancer cells. J Exp Clin Cancer Res. 2014;33(1):3. Published 2014 Jan 6

[4]Mao W, Zhu Z. Parthenolide inhibits hydrogen peroxide‑induced osteoblast apoptosis. Mol Med Rep. 2018;17(6):8369-8376

[5]Li XH, Xiao T, Yang JH, et al. Parthenolide attenuated bleomycin-induced pulmonary fibrosis via the NF-κB/Snail signaling pathway. Respir Res. 2018;19(1):111. Published 2018 Jun 5

[6]Popiolek-Barczyk K, Kolosowska N, Piotrowska A, et al. Parthenolide Relieves Pain and Promotes M2 Microglia/Macrophage Polarization in Rat Model of Neuropathy. Neural Plast. 2015;2015:676473