产品说明书
Adapalene
 |
同义名 : | CD271 |
| CAS号 : | 106685-40-9 | |
| 货号 : | A105293 | |
| 分子式 : | C28H28O3 | |
| 纯度 : | 99% | |
| 分子量 : | 412.52 | |
| MDL号 : | MFCD03106112 | |
| 存储条件： |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 9 mg/mL(21.82 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
IP 2% DMSO+water 0.2 mg/mL clear PO 0.5% CMC-Na 42 mg/mL suspension |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Adapalene (CD271) is a third-generation synthetic retinoid commonly used in acne research. It functions as a potent agonist of retinoic acid receptors (RAR), demonstrating AC50 values of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, and RARα, respectively. Additionally, adapalene inhibits the enzymatic activity of glutamate oxaloacetate transaminase 1 (GOT1) in a non-competitive manner and has shown anti-tumor activity in various studies[1].[2].[3]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT02731105 | Acne Vulgaris | Phase 4 | Completed | - | Germany ... 展开 >> Universitätsklinikum Carl Gustav Carus; Klinik und Poliklinik für Dermatologie Dresden, Saxony, Germany, 01307 收起 << |
| NCT02620813 | Acne Vulgaris | Phase 4 | Recruiting | May 2019 | United States, California ... 展开 >> Dermatology Research Area Recruiting Davis, California, United States, 95616 Contact: Negar Foolad, MAS 916-734-1509 nfoolad@ucdavis.edu Contact: Lauren A Hassoun, BS 916-734-6550 lahassoun@ucdavis.edu Principal Investigator: Raja K Sivamani, MD UC Davis Department of Dermatology Recruiting Sacramento, California, United States, 95816 Contact: Raja Sivamani, MD rajasivamani@gmail.com 收起 << |
| NCT02442817 | Schizophrenia | Phase 4 | Unknown | May 2017 | United States, Nevada ... 展开 >> University of Nevada School of Medicine Recruiting Reno, Nevada, United States, 89503 Contact: Brian Kirkpatrick, MD 775-682-8449 bkirkpatrick@medicine.nevada.edu Principal Investigator: Brian Kirkpatrick, MD 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.42mL 0.48mL 0.24mL |
12.12mL 2.42mL 1.21mL |
24.24mL 4.85mL 2.42mL |
| 参考文献 |
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