产品说明书
SPDP
 |
同义名 : | - |
| CAS号 : | 68181-17-9 | |
| 货号 : | A104705 | |
| 分子式 : | C12H12N2O4S2 | |
| 纯度 : | 97% | |
| 分子量 : | 312.36 | |
| MDL号 : | MFCD00009636 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 150 mg/mL(480.22 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
|
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | SPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. It is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs)[2]. DAC micelles were chemically linked onto the PAA-BP-modified stents by using N-succinimidyl-3-(2-pyridyldithiol)-propionate (SPDP) as a crosslinker[3]. The Vi (capsular polysaccharide) was bound to the porins by a heterobifunctional cross-linking reagent, N-succinimidyl-3-(2-pyridyl dithio)-propionate (SPDP)[4]. Based on the results obtained from morphological characterization, in vitro release, and therapeutic efficacy in cells, N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)-modified ABNs (ABN-SPDP) was chosen. Since ABN-SPDP are formed with disulfide linkage, the drug release is facilitated under a highly reducing environment present in the tumor sites[5]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT01166048 | Chronic Low Back Pain | Phase 4 | Completed | - | Austria ... 展开 >> Department of Special Anesthesia and Pain Therapy, Medical University of Vienna, AKH Vienna Vienna, Austria, 1090 收起 << |
| NCT02968433 | Parkinson Disease(PD) | Phase 1 | Active, not recruiting | December 2018 | United States, California ... 展开 >> Stanford Movement Disorders Clinic Stanford, California, United States, 94304 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
3.20mL 0.64mL 0.32mL |
16.01mL 3.20mL 1.60mL |
32.01mL 6.40mL 3.20mL |
| 参考文献 |
|---|