Mocetinostat

产品说明书

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Chemical Structure| 726169-73-9 同义名 : -
CAS号 : 726169-73-9
货号 : A102453
分子式 : C23H20N6O
纯度 : 98%
分子量 : 396.445
MDL号 : MFCD10565970
存储条件：

Pure form Keep in dark place,Sealed in dry,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(126.12 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：

30% PEG400+0.5% Tween80+5% Propylene glycol+water 30 mg/mL suspension

生物活性
靶点

  • HDAC3

    HDAC3, IC50:1.66 μM

  • HDAC11

    HDAC11, IC50:0.59 μM

  • HDAC2

    HDAC2, IC50:0.29 μM

  • HDAC1

    HDAC1, IC50:0.15 μM
描述 Mocetinostat is a potent HDAC inhibitor with IC50 of 0.15, 0.29 and 1.66 μM for HDAC 1, HDAC 2 and HDAC 3, respectively.
细胞研究
细胞系 浓度 检测类型 检测时间 活动说明 数据源
ANBL6 1 μM Function Assay 24 h enhances 5-AC-induced MAGE-A3 gene expression 21171821
AsPC-1 Growth Inhibition Assay EC50=3.9 μM 21375679
BT549 Growth Inhibition Assay 48 h IC50=4.38 μM 26378038
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.52mL

0.50mL

0.25mL

12.61mL

2.52mL

1.26mL

25.22mL

5.04mL

2.52mL
参考文献

[1]Cavasin MA, Demos-Davies K, et al. Selective class I histone deacetylase inhibition suppresses hypoxia-induced cardiopulmonary remodeling through an antiproliferative mechanism. Circ Res. 2012 Mar 2;110(5):739-48.

[2]Fournel M, Bonfils C, et al. MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo. Mol Cancer Ther. 2008 Apr;7(4):759-68.