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D-Pinitol

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Chemical Structure| 10284-63-6 同义名 : 3-O-Methyl-D-chiro-inositol;3-O-methyl-Chiroinositol;Inzitol;D-(+)-Pinitol;Pinitol;Methylinositol
CAS号 : 10284-63-6
货号 : A101964
分子式 : C7H14O6
纯度 : 97%
分子量 : 194.183
MDL号 : MFCD00216659
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(617.98 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 D-pinitol, a compound isolated from Pinaceae and Leguminosae plants, possess insulin-like properties. D-pinitol was administrated to the diabetic rats as two doses [30, 60 mg/(kg·body weight·day)]. The level of fasting blood glucose (FBG) was decreased 12.63% in the high-dosage group, and the ability of oral glucose tolerance was improved in D-pinitol-treated groups[3]. D-pinitol enhanced glucose-induced insulin secretion, which may account to enhances hepatic lipogenesis and TG (triglycerides) deposition in MPIN mice[4]. D-pinitol increased the concentration of nitrite, which was inhibited by L-NAME and calmidazolium (10 μM). D-pinitol increased the phosphorylation level of eNOS activation site at Ser1177 and reduced the phosphorylation level of its inactivation site at Thr495. In normotensive mice, the intraperitoneal administration of D-pinitol (10 mg/kg) induced a significant reduction of the SBP after 30 min[5]. D-pinitol treatment induces the apoptosis in human leukemic cells by generating intracellular ROS and modulating apoptotic protein expression[6]. D-pinitol ameliorated the skin abrasion and abridged epithelial thickness, inflammation numbers, and collagen-occupied regions in IMQ-induced psoriasis-like mice[7].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00470418 Alzheimer Disease ... 展开 >> Dementia 收起 << Phase 2 Completed - United States, New York ... 展开 >> VA Medical Center, Bronx Bronx, New York, United States, 10468 收起 <<
NCT00470418 - Completed - -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.15mL

1.03mL

0.51mL

25.75mL

5.15mL

2.57mL

51.50mL

10.30mL

5.15mL
参考文献

[1]Rengarajan T, Nandakumar N, et al. D-pinitol promotes apoptosis in MCF-7 cells via induction of p53 and Bax and inhibition of Bcl-2 and NF-κB. Asian Pac J Cancer Prev. 2014;15(4):1757-62.

[2]Lin TH, Tan TW, et al. D-pinitol inhibits prostate cancer metastasis through inhibition of αVβ3 integrin by modulating FAK, c-Src and NF-κB pathways. Int J Mol Sci. 2013 May 8;14(5):9790-802.

[3]Gao Y, Zhang M, Wu T, Xu M, Cai H, Zhang Z. Effects of D-Pinitol on Insulin Resistance through the PI3K/Akt Signaling Pathway in Type 2 Diabetes Mellitus Rats. J Agric Food Chem. 2015 Jul 8;63(26):6019-26

[4]Silva JÚnior JAD, Silva ACVFD, Figueiredo LS, Araujo TR, Freitas IN, Carneiro EM, Ribeiro ES, Ribeiro RA. D-Pinitol Increases Insulin Secretion and Regulates Hepatic Lipid Metabolism in Msg-Obese Mice. An Acad Bras Cienc. 2020 Nov 20;92(4):e20201382

[5]Moreira LN, Silva JF, Silva GC, Lemos VS, Cortes SF. Activation of eNOS by D-pinitol Induces an Endothelium-Dependent Vasodilatation in Mouse Mesenteric Artery. Front Pharmacol. 2018 May 22;9:528

[6]Yao X, Shi K, Yang Y, Gu X, Tan W, Wang Q, Gao X, Priya Veeraraghavan V, Mohan SK, Jin S. D-Pinitol treatment induced the apoptosis in human leukemia MOLT-4 cells by improved apoptotic signaling pathway. Saudi J Biol Sci. 2020 Aug;27(8):2134-2138

[7]Ma J, Feng S, Ai D, Liu Y, Yang X. D-Pinitol Ameliorates Imiquimod-Induced PsoriasisLike Skin Inflammation in a Mouse Model via the NF-κB Pathway. J Environ Pathol Toxicol Oncol. 2019;38(3):285-295