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Azathioprine

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Chemical Structure| 446-86-6 同义名 : 硫唑嘌呤 ;BW 57-322;Azamune;Azathioprine, US brand name: Imuran. Foreign brand name: Imurel. Abbreviations: AZA. AZTP.;NSC 39084;Imuran;Azoran
CAS号 : 446-86-6
货号 : A101947
分子式 : C9H7N7O2S
纯度 : 98%
分子量 : 277.263
MDL号 : MFCD00055974
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(180.33 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：

IP 2% DMSO+2% Tween80+40% PEG300+water 3 mg/mL clear

PO 0.5% CMC-Na 62 mg/mL suspension

生物活性
靶点

  • Rac
描述 Azathioprine is an immunosuppressive drug, inhibiting purine synthesis and GTP-binding protein Rac1 activation, used in the treatment of organ transplantation and autoimmune diseases.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00745329 - Unknown - -
NCT01235689 Crohn's Disease Phase 3 Completed - -
NCT00615173 Kidney Diseases ... 展开 >> Lupus Nephritis Tacrolimus Induction Phase Maintenance Phase 收起 << Phase 3 Completed - China, Guangdong ... 展开 >> The 1st Affiliated Hospital, Sun Yet-sen University Guangzhou, Guangdong, China, 510080 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.61mL

0.72mL

0.36mL

18.03mL

3.61mL

1.80mL

36.07mL

7.21mL

3.61mL
参考文献

[1]Poppe D, Tiede I, et al. Azathioprine suppresses ezrin-radixin-moesin-dependent T cell-APC conjugation through inhibition of Vav guanosine exchange activity on Rac proteins. J Immunol. 2006 Jan 1;176(1):640-51.

[2]Tiede I, Fritz G, et al. CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes. J Clin Invest. 2003 Apr;111(8):1133-45.