Clorgyline HCl
产品说明书
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同义名 : | N-2,4-Dichlorophenoxypropyl-N-methylpropargylamine;Clorgyline (hydrochloride);Clorgyline hydrochloride |
| CAS号 : | 17780-75-5 | |
| 货号 : | A101686 | |
| 分子式 : | C13H16Cl3NO | |
| 纯度 : | 99%+ | |
| 分子量 : | 308.631 | |
| MDL号 : | MFCD00052012 | |
| 存储条件： |
Pure form Sealed in dry,Room Temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(340.21 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 100 mg/mL(324.01 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
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| 描述 | Clorgiline Hydrochloride is an irreversible and selective MAO-A inhibitor with IC50 of 6.061 ± 0.262 µM[3]. MAO A inhibitors reduce the growth of prostate cancer, drug sensitive and resistant gliomas and classical Hodgkin lymphoma, and enhance standard chemotherapy[4]. The MAOA inhibitor clorgyline reduced the growth of L1236 cells and U-HO1 cells, and shRNA knockdown of MAOA reduced the growth of L1236 cells. Combined treatment with clorgyline and ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine) was more effective in reducing cell growth than either regimen alone[5]. In human SH-SY5Y cells expressing MAO-A but not MAO-B, hypoxia significantly increased the MAO-A expression, which was blocked by M30 or clorgyline[6]. Clorgyline, induced secretory differentiation in primary cultures of normal basal epithelial cells and high-grade PCa (primary prostate cancer). Treatment with clorgyline in vitro inhibited growth and altered the transcriptional pattern of VCaP cells in a manner consistent with the pro-differentiation and anti-oncogenic effects seen in treated primary PCa cells. Clorgyline treatment of mice bearing VCaP xenografts slowed tumor growth and induced transcriptome changes similar to those noted in vitro[7]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.24mL 0.65mL 0.32mL |
16.20mL 3.24mL 1.62mL |
32.40mL 6.48mL 3.24mL |
| 参考文献 |
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