产品说明书

Azaperone

Print
Chemical Structure| 1649-18-9 同义名 : 阿扎哌隆 ;R-1929;Fluoperidol;Eucalmyl;Suicalm;Azaperon;Stresnil;NSC 170976
CAS号 : 1649-18-9
货号 : A101450
分子式 : C19H22FN3O
纯度 : 98%
分子量 : 327.396
MDL号 : MFCD00866692
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(152.72 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：

IP 2% DMSO+2% Tween80+30% PEG300+water 6 mg/mL clear

PO 0.5% CMC-Na 62 mg/mL suspension

生物活性
靶点

  • Dopamine receptor
描述 Administration of azaperone at weaning had a profound effect on preovulatory LH secretion as well as growth kinetics and estrogenicity of ovarian antral follicles[3]. Thiafentanil and azaperone, with or without etorphine, delivered rapid safe, effective, reversible field anaesthesia in healthy swamp buffalo[4]. Using azaperone alone the duration of immobility was 1.9 to 10.8 hours for mice and 0.9 to 2.4 hours for rats. The withdrawal reflex was not eliminated from mice receiving azaperone alone; however, the withdrawal reflex was eliminated from 0.9 to 2.4 hours in rats receiving azaperone. Azaperone produced a tachypnea in rats and male mice while a depressed respiratory rate was observed in female mice. Overall, azaperone alone was shown to provide sedation in mice as compared to a dose dependent anesthesia in rats. Azaperone and the azaperone-ketamine combination appear to be a suitable alternative to sedatives and anesthetics currently used in rats and mice[5].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01486615 Anxiety Phase 4 Completed - Nepal ... 展开 >> B. P. Koirala Institute of Health Sciences Dharan, Koshi, Nepal, 56700 Dr Krishna Pokharel Dharan, Koshi, Nepal, 56700 收起 <<
NCT01486615 - Completed - -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.05mL

0.61mL

0.31mL

15.27mL

3.05mL

1.53mL

30.54mL

6.11mL

3.05mL
参考文献

[1]Lahrmann KH, Baars J, et al. [Perioperative intensive-medical investigations regarding compatibility of the ketamine-azaperone-general anesthesia in pigs] . Berl Munch Tierarztl Wochenschr. 2014 Jan-Feb;127(1-2):3-11.

[2]Bettschart-Wolfensberger R, Stauffer S, et al. Racemic ketamine in comparison to S-ketamine in combination with azaperone and butorphanol for castration of pigs. Schweiz Arch Tierheilkd. 2013 Dec;155(12):669-75.

[3]Schwarz T, Zięcik A, Murawski M, et al. The influence of azaperone treatment at weaning on reproductive function in sows: ovarian activity and endocrine profiles during the weaning-to-ovulation interval. Animal. 2018;12(10):2089‐2097

[4]Bryant B, Pittard S, Jordan NR, McMahon CR. Chemical capture of wild swamp buffalo (Bubalus bubalis) in tropical northern Australia using thiafentanil, etorphine and azaperone combinations. Aust Vet J. 2019;97(1-2):33‐38

[5]Olson ME, Renchko P. Azaperone and azaperone-ketamine as a neuroleptic sedative and anesthetic in rats and mice. Lab Anim Sci. 1988;38(3):299‐304