产品说明书
iFSP1
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同义名 : | - |
| CAS号 : | 150651-39-1 | |
| 货号 : | A1007917 | |
| 分子式 : | C20H13N5 | |
| 纯度 : | 99%+ | |
| 分子量 : | 323.351 | |
| MDL号 : | MFCD01572665 | |
| 存储条件： |
粉末 Keep in dark place,Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 12 mg/mL(37.11 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Ferroptosis, controlled by the selenoenzyme GPX4, is an iron-dependent form of necrotic cell death marked by oxidative damage to phospholipids. iFSP1 is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1) with an EC50 of 103 nM. iFSP1 (0.001-1 μM; 24 h) dose-dependently inhibited the GPX4-knockout cell growth, but did not inhibit the wild type cell growth. Treatment with the ferroptosis inhibitor Lip-1 protects GPX4-knockout cells from iFSP1-induced ferroptosis. iFSP1 (3 μM; 24 h) resulted in an obvious toxicity of RSL3 (a ferroptosis inducer) in a panel of genetically engineered (FSP1-knockout) human cancer cell lines[3]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.09mL 0.62mL 0.31mL |
15.46mL 3.09mL 1.55mL |
30.93mL 6.19mL 3.09mL |
| 参考文献 |
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