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ZLN005

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Chemical Structure| 49671-76-3 同义名 : -
CAS号 : 49671-76-3
货号 : A100765
分子式 : C17H18N2
纯度 : 99%+
分子量 : 250.338
MDL号 : MFCD01560221
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 20 mg/mL(79.89 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a key regulator of energy homeostasis. Dysregulation of PGC-1α is correlated with the development of insulin resistance and type 2 diabetes. ZLN005 is a small molecule that has been shown to increase the mRNA level of PGC-1α in L6 myotubes in a dose-dependent manner (5 – 20μM). It leds to a threefold increase in the PGC-1α gene expression over the control group at a concentration of 20μM after 24 h. ZLN005 at 10μM increased the mRNA expressions of GLUT4, NRF1, ERRα, cox5b, and acyl-CoA oxidase. ZLN005 at 20μM resulted in a 1.8-fold improvement in glucose uptake after 24 h of treatment. Chronic oral administration of db/db mice with 15mg/kg/day ZLN005 for 6 weeks improved glucose tolerance and pyruvate tolerance, and decreased insulin resistance in comparison with the control group. ZLN005 treatment also decreased the plasma non-esterified fatty acids and triglyceride levels in db/db mice by 20% and 37%, respectively[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.99mL

0.80mL

0.40mL

19.97mL

3.99mL

2.00mL

39.95mL

7.99mL

3.99mL
参考文献

[1]Li W, Li X, Wang B, et al. ZLN005 protects cardiomyocytes against high glucose-induced cytotoxicity by promoting SIRT1 expression and autophagy. Exp Cell Res. 2016 Jul 1;345(1):25-36.

[2]Zhang LN, Zhou HY, et al. Novel small-molecule PGC-1α transcriptional regulator with beneficial effects on diabetic db/db mice. Diabetes. 2013 Apr;62(4):1297-307.

[3]Zhang LN, Zhou HY, Fu YY, Li YY, Wu F, Gu M, Wu LY, Xia CM, Dong TC, Li JY, Shen JK, Li J. Novel small-molecule PGC-1α transcriptional regulator with beneficial effects on diabetic db/db mice. Diabetes. 2013 Apr;62(4):1297-307.