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Olesoxime

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Chemical Structure| 22033-87-0 同义名 : Tro 19622;NSC 21311;RG6083
CAS号 : 22033-87-0
货号 : A100616
分子式 : C27H45NO
纯度 : 98%
分子量 : 399.652
MDL号 : MFCD00201488
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(125.11 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Olesoxime (TRO 19622) exposure (ranging from 0.1 to 10 µM) 1 hour after plating significantly protects primary embryonic rat spinal MNs from cell death, with a 74±10% survival rate at 10 µM when supported by neurotrophic factors. Its EC50 for this effect is 3.2±0.2 µM. Besides preserving MN cell bodies, Olesoxime also promotes neurite outgrowth; at 1 µM, it enhances cell survival by 38% and increases neurite outgrowth per cell by 54%[1]. Olesoxime belongs to a novel class of cholesterol-oximes, targets outer mitochondrial membrane proteins, concentrates at mitochondria, and prevents oxidative stress-mediated permeability transition pore opening[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.50mL

0.50mL

0.25mL

12.51mL

2.50mL

1.25mL

25.02mL

5.00mL

2.50mL
参考文献

[1]Lladó-Pelfort L, et al. In vivo electrophysiological and neurochemical effects of the selective 5-HT1A receptor agonist, F13640, at pre- and postsynaptic 5-HT1A receptors in the rat. Psychopharmacology (Berl). 2012 May;221(2):261-72.

[2]Bordet T, et al. Olesoxime (TRO19622): A Novel Mitochondrial-Targeted Neuroprotective Compound. Pharmaceuticals (Basel). 2010 Jan 28;3(2):345-368

[3]Bordet T, et al. Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis. J Pharmacol Exp Ther. 2007 Aug;322(2):709-20.