3-Methyltoxoflavin

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Chemical Structure| 32502-62-8 同义名 : -
CAS号 : 32502-62-8
货号 : A1005353
分子式 : C8H9N5O2
纯度 : 99%+
分子量 : 207.189
MDL号 : MFCD00449892
存储条件：

Pure form Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(241.33 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 3-Methyltoxoflavin is a potent PDI inhibitor with an IC50 value of 170 nM. 3-Methyltoxoflavin is toxic to human glioblastoma cell lines. Bru-seq analysis showed that 3-Methyltoxoflavin induced Nrf2 antioxidant response, ER stress response and autophagy. Specifically, 3-Methyltoxoflavin upregulated the transcription and protein expression of heme oxygenase 1 and SLC7A11, and inhibited PDI target genes such as TXNIP and EGR1. Interestingly, 3-Methyltoxoflavin-induced cell death is not through apoptosis or necrosis, but through a hybrid process of autophagy and iron metamorphosis[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.83mL

0.97mL

0.48mL

24.13mL

4.83mL

2.41mL

48.27mL

9.65mL

4.83mL
参考文献

[1]Kyani A, et al. Discovery and Mechanistic Elucidation of a Class of Protein Disulfide Isomerase Inhibitors for the Treatment of Glioblastoma. ChemMedChem. 2018 Jan 22;13(2):164-177.