IBR2

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Chemical Structure| 313526-24-8 同义名 : -
CAS号 : 313526-24-8
货号 : A1005253
分子式 : C24H20N2O2S
纯度 : 98%+
分子量 : 400.493
MDL号 : MFCD00991660
存储条件：

Pure form Inert atmosphere,Room Temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(262.18 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 IBR2 is a potent and specific RAD51 inhibitor that inhibits RAD51-mediated repair of DNA double-strand breaks. IBR2 disrupts RAD51 multimerisation, accelerates proteasome-mediated degradation of RAD51 proteins, inhibits cancer cell growth, and induces apoptosis[1][2].In IBR2-treated cancer cells, RAD51 is rapidly degraded and homologous recombination repair is impaired, leading to cell death. For most of the cancer cell lines tested, the IC50 value for the IBR2 prodrug ranged from 12-20 μM. IBR2 inhibited the growth of MBA-MD-468 with an IC50 value of 14.8 μM[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.50mL

0.50mL

0.25mL

12.48mL

2.50mL

1.25mL

24.97mL

4.99mL

2.50mL
参考文献

[1]Jiewen Zhu, et al. A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia. EMBO Mol Med. 2013 Mar;5(3):353-65.

[2]Zhu J, et al. Synthesis, molecular modeling, and biological evaluation of novel RAD51 inhibitors. Eur J Med Chem. 2015;96:196-208.