生物活性 | |||
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描述 | ML351 is a novel chemotype and the first reported selective inhibitor of 15-LOX-1 with IC50 value of 200 nM. It is a tight binding, mixed inhibitor which could protect against oxidative glutamate toxicity in mouse neuronal cells (HT-22) and significantly reduced infarct size in an in vivo mouse model for ischemic stroke. |
实验方案 | |||
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1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
4.01mL 0.80mL 0.40mL |
20.06mL 4.01mL 2.01mL |
40.12mL 8.02mL 4.01mL |
参考文献 |
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