产品说明书

Bozitinib

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Chemical Structure| 1440964-89-5 同义名 : PLB-1001;CBT-101;Vebreltinib
CAS号 : 1440964-89-5
货号 : A1002083
分子式 : C20H15F3N8
纯度 : 98%+
分子量 : 424.382
MDL号 : N/A
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(117.82 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Bozitinib (PLB-1001) is a c-MET kinase inhibitor known for its high selectivity and ability to penetrate the blood-brain barrier. As an ATP-competitive small-molecule inhibitor, Bozitinib (PLB-1001) attaches to the standard ATP-binding pocket found in the tyrosine kinase superfamily[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.36mL

0.47mL

0.24mL

11.78mL

2.36mL

1.18mL

23.56mL

4.71mL

2.36mL
参考文献

[1]Hu H, et al. Mutational Landscape of Secondary Glioblastoma Guides MET-Targeted Trial in Brain Tumor. Cell. 2018 Nov 29;175(6):1665-1678.e18.