BB-Cl-Amidine

产品说明书

Print
Chemical Structure| 1802637-39-3 同义名 : -
CAS号 : 1802637-39-3
货号 : A1001784
分子式 : C26H26ClN5O
纯度 : 99%+
分子量 : 459.97
MDL号 : MFCD31746879
存储条件：

Pure form Inert atmosphere,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(260.89 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 BB-Cl-amidine is a novel pan-PAD inhibitor with potency to PAD1-4, with half-life of 1.75h in vivo. BB-Cl-amidine exhibited potency against U2OS osteosarcoma cell viability with EC50 value of 8.8μM post 72-hour treatment. Inhibition of PAD by 20μM or 200μM BB-Cl-amidine could prevent PMA-induced neutrophil extracellular trap formation of bone marrow neutrophils prepared from 8-week-old MRL/lpr mice. And this effect could be observed in an in vivo study of MRL/lpr mice daily subcutaneous injected with BB-Cl-amidine at dose of 1mg/kg from 8 to 14 weeks of age. And improved vascular function, and decreasesd IFN signature in bone marrow and kidney, decreased IC deposition in kidneys and reduced proteinuria, improved skin involvement could be found after administration of BB-Cl-amidine.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.17mL

0.43mL

0.22mL

10.87mL

2.17mL

1.09mL

21.74mL

4.35mL

2.17mL